0887 Divergent Slow wave sleep and Alzheimer's disease Plasma Biomarkers’ Associations in Black and White Cognitive Normal Older-Adults

Abstract Introduction We determined whether slow wave sleep is associated with plasma levels of Aβ40, Aβ42, Aβ42/Aβ40, Tau, tau/Aβ42 and NfL this relationship differed between Blacks/African-Americans non-Hispanic Whites. Methods This was a cross-sectional analysis baseline data from 171 community-dwelling cognitively normal older-adults, participating in ongoing NYU studies on memory, aging. Non-rapid eye movement (NREM) (SWS) duration calculated 2 nights in-lab NPSGs. Plasma Tau were using single molecule array (SIMOA). Associations NREM SWS AD biomarker assessed adjusted generalized linear models Pearson correlation after normalization. Analyses for age, sex, BMI, race, education. Results Of the subjects (128 Whites 43 Blacks/African-Americans), 112 (65.5%) females, mean (SD) age 68.6 (6.6) years, BMI 27.6 (6.1) kg/m**2, education 16.9 (2.1). There no racial differences AHI4%. Compared to Whites, had significantly lower years (14.2 vs. 17.2, p <.01), Aβ40 (248.3 262.5 pg/ml) (11.4 15.2 p<.05 both. significant Tau/Aβ40 Tau/Aβ42 (p>.05 all). not or tau overall sample However, negatively correlated Aβ42 (r=-0.28, p<=0.05), (r=-0.087, p=0.72), though significant, (r=-0.153, p=0.27), significant. In Black/African-Americans, positively (r=0.48, p=0.05), (r=0.32, p=0.04), (r=0.52, p=0.04). tau/Aβ42, tau/Aβ40 across subgroups. Conclusion Race-specific divergent associations & may suggest SDOH factors mechanisms that could influence AD-risk older-adults. Support (if any) AASMBTS#231-BS-20, NIAK23AG068534A, AARG-D- 21-848397, BFFA2022033S